LRRK2 and Parkinson disease: Additionally, several variants were shown to moderately increase the risk for PD, such as p.Q416* and p.A419V located in the ARM domain [9,10], p.R1628P and p.M1646T within the COR domain [10,11,12] and p.G2385R within the WD40 domain [13] Interestingly, a non-coding LRRK2 variant c.622C > T was nominated by Genome-Wide Association Studies (GWAS) to also affect the LRRK2 expression and mediate PD risk [14].