To gain insights into whether TLR9/BCR co-activation causes similar remodeling in primary B-cells and in MCD DLBCL, we cross-compared proteomes from aIgM/CpG-stimulated primary B-cells or the tumor-derived MCD DLBCL HBL1 cell line with resting primary B-cells. The gene discussed is TLR9; the disease is diffuse large B-cell lymphoma.