Previous analysis of TDP-43 pathology within the amygdala has demonstrated TDP-43 pathology in 38.5% of ALS-FTSD cases and an increased prevalence of pTDP-43 pathology in cases with dementia; however, many cases lacked adequate and/or comparable clinical information, limiting further conclusive analysis (14). The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.