CD8A and neoplasm: In particular, we find that tumor antigen is selectively taken up by cDC2, rather than cDC1, which would be expected to skew the forthcoming adaptive immune response away from the generation of CD8 + T cells and Th1, and toward Th2, Th17, or Treg specification, thus impairing tumor clearance.13 This phenomenon may account for our observation that these tumors so reliably establish and progress upon delivery to the airway.