TP53 and non-small cell lung carcinoma: Notwithstanding, these murine tumors harbor much fewer simple somatic mutations compared to their human counterparts, resulting in less immunogenicity.4, 5 Kirsten rat sarcoma viral oncogene homolog (KRAS) and tumor suppressor p53 (TP53) genes are mutated at a high frequency in non-small lung cancer (NSCLC) patients.