Analysis of DepMAP data revealed that the knockout effect of peroxisome genes (i.e., PEX1) had no significant correlation with the expression of either HIF2A or MYC while SCD knockout effect was negatively correlated with MYC expression (Fig. 6- figure supplement 2A-D), suggesting that SCD is a MYC cancer dependency gene. Here, EPAS1 is linked to cancer.