To investigate this phenomenon further, we stained lung tissue of mice bearing 14-day orthotopic tumours for von Willebrand Factor (vWF), which is strongly expressed in the endothelium of veins and arteries but not of capillaries27, along with VE-cadherin, which is homogeneously expressed in all endothelial cells in the lung28 (Fig. 1d and Extended Data Fig. 1a). The gene discussed is CDH5; the disease is neoplasm.