CLU and Alzheimer disease: Indeed, the endosome-lysosomal system appears to be a major pathway affected by aging and AD in tNeurons, with many proteins associated with lysosomes (e.g. ACE, ANPEP, CLU, SLC15A3) or lysosomal quality control (LQC) altered in aging (e.g. CNN2, HspB1) and AD (e.g. DPP7, PLBD2, PLD3, TAGLN).