Also consistent with our tNeuron findings, we observed increased colocalization of Galectin-3 with LAMP2 in neurons of AD patients (Extended Data Fig.11b) and Aβ deposits associated with LAMP2-positive lysosomes in both extra-cellular and intra-neuronal plaques using 6E10 antibody in AD patient’s cortex (Fig.4c, and Extended Data Fig.11c). The gene discussed is LGALS3; the disease is Alzheimer disease.