Indeed, the endosome-lysosomal system appears to be a major pathway affected by aging and AD in tNeurons, with many proteins associated with lysosomes (e.g. ACE, ANPEP, CLU, SLC15A3) or lysosomal quality control (LQC) altered in aging (e.g. CNN2, HspB1) and AD (e.g. DPP7, PLBD2, PLD3, TAGLN). This evidence concerns the gene CNN2 and Alzheimer disease.