Interestingly, Chinese Glioma Genome Atlas (CGGA) data accessed via GlioVis showed worsened prognosis in patients with high IGF2 expression (Supplementary Figure 1E).18 Collectively, these data suggested that oHSV therapy-induced intratumoral IGF2 expression and secretion activates IGF1R signaling, contributing to oHSV resistance. Here, IGF1R is linked to central nervous system cancer.