Single-cell RNA-seq (scRNA-Seq) data analyzing GBM patient samples shows that IGF2 is mostly expressed in neoplastic and vascular cells, not in neuronal cells in which oHSVs do not replicate.40 Additionally, IGF2 expression is significantly increased directly around the oHSV replication area (Figure 1H). This evidence concerns the gene IGF2 and glioblastoma.