IGF1R and central nervous system cancer: Several in vitro and in vivo studies have shown that inhibition of IGF1R signaling induces an antitumor immune response in BC and GBM models.9–12 To assess whether oHSV-D11mt can activate immune cells and induce cytotoxicity towards infected cancer cells, we performed an in vitro co-culture assay of rHSVQ- or oHSV-D11mt-infected glioma and BC cells with peripheral blood mononuclear cells (PBMCs).