Investigations into expression of associative plasticity in AD models, unsurprisingly, showed that STC is not expressed using the strong-before-weak protocol in APP/presenilin 1 (PS1) mice (APPswe/PS1dE9 double transgenic mice) or induced AD mice models (exogenous Aβ(1-42)) [164–168]. This evidence concerns the gene PSEN1 and Alzheimer disease.