Area under the curve (AUC) was calculated and the Spearman's rho, and the coefficient of determination (R<sup>2</sup>) were used to calculate the correlations between aMMP-8, azurocidin, and periodontal parameters.<h4>Results</h4>Statistically significant differences were observed for aMMP-8 levels but not for azurocidin between healthy implants, implants with mucositis, and those with peri-implantitis (13.65 ± 7.18, 32.33 ± 21.20, and 73.07 ± 43.93 ng/mL, respectively), (Kruskall-Wallis test p < .05). Here, AZU1 is linked to mucositis.