Surprisingly, we noticed that there was a positive correlation between CD8+T cells infiltration and GSDME expression (Fig. 1g, h) and higher level of CD8+T cells predicted favorable RFS and OS of CRC patients (Supplementary Fig. 1a, b), which suggested GSDME might influence the CD8+T cells in tumor microenvironment (TME). The gene discussed is GSDME; the disease is neoplasm.