GSDME and neoplasm: According to transcriptional levels, we consolidated that GSDME was downregulated in tumor tissues and divided them into two groups of the same numbers of patients by 2−ΔCT (17 vs. 17, GSDMElow vs. GSDMEhigh) (Supplementary Fig. 3c), which was consistent with results of division of two group by the percentage of CD45−GSDMEhigh cells (Supplementary Fig. 3d).