Additionally, the release of exosomes containing damaged DNA has been found to induce DCs maturation through the cGAMP-STING-TBK1 pathway, while the secretion of IFN-β activates CD8+T cells, resulting in the release of IFN-γ and subsequent inhibition of GSH and GPX4 expression in tumor cells [46]. The gene discussed is IFNG; the disease is neoplasm.