CFI and age-related macular degeneration: Importantly, 2015, 2020, and 2022 studies in distinct European and US cohorts revealed that rare CFI variants that resulted in haploinsufficiency (low antigenic levels in serum, referred to as “type I” variants) were strongly associated with advanced AMD with odd ratios (ORs) >10 (36, 37) and ORs 3.1 to 7.8 (38).