CFI and nervous system disorder: In addition to isolation in AMD, CFI RVs are also observed in rare renal and neurological diseases such as atypical hemolytic uremic syndrome (aHUS) (46) (with mutation dependent treatment differences observed (47), C3 glomerulopathy/membranoproliferative glomerulonephritis (48), and deficiency of factor I with cerebral inflammation syndrome, in addition to complete CFI immunodeficiency (27).