The mechanisms underpinning C3b′s contribution to AMD are thought to primarily rely on the recruitment and activation of immune cells in the retina and choroid through C3b/iC3b-CR3 interactions and the fueling of a proinflammatory microenvironment by C5a generation, well reviewed in (79, 80). The gene discussed is CRIPTO3; the disease is age-related macular degeneration.