MAPT and Alzheimer disease: Hence, the lack of typical apoptotic blebbing morphology in degenerating neurons, the exceedingly low frequency of caspase-3 positive neurons (which does not explain the substantial neuronal loss) [10], and the presence of caspases within Tau tangles [8, 50, 139] all imply alternative functions of caspases in AD, rather than their involvement solely in apoptotic cell death [26, 29, 32, 52].