Notably, genetic studies, in particular genome-wide association studies (GWAS) have identified several risk genes of AD which are operating in the endo-lysosomal network (ELN), such as PICALM, PLD3, BIN1, CSTD, CLU, UBQLN1, GRN, and SORL1 [12, 15, 74, 109]. The gene discussed is PLD3; the disease is Alzheimer disease.