Alzheimer’s disease (AD) may have multiple primary etiologies (genetic, sporadic, environmental, and infection) [15, 68, 90] but is defined by a common characteristic neuropathology and symptomatology, including extracellular deposition of amyloid plaques, intracellular deposition of hyperphosphorylated Tau tangles, neurovascular changes, reactive gliosis, cognitive impairment, granulovacuolar degeneration (GVDs), and neurodegeneration [6, 86, 153]. This evidence concerns the gene MAPT and Alzheimer disease.