Other target molecules of epidermal adhesion are now identified in the pathogenesis of pemphigus, as well as mitochondrial proteins, cholinergic receptors, and other molecules, which act synergistically with anti-Dsg1 and Dsg3 antibodies in epidermal acantholysis.9, 10, 11, 12, 13, 14, 15, 16, 17, 18. The gene discussed is DSG1; the disease is pemphigus.