To test whether the loss of ACSS2 in stroma cells (HS-5 ACSS2-KO) impacted the viability of leukemic cells, we first examined apoptosis levels by treating leukemia cocultures with histone deacetylase inhibitors (Api, CBHA, and SAHA), with only API and SAHA treatment resulting in partial restoration of apoptosis in KG1a cocultured with HS-5 ACSS2-WT (Supplementary Fig. 4C). The gene discussed is ACSS2; the disease is leukemia.