In contrast, KG1a, OCI-AML3 and K562 pre-exposed to HS-5 ACSS2-KO had a markedly diminished OCR (2.7-fold, 1.7-fold, and 1.5-fold, respectively, Supplementary Fig. 4D) compared to leukemia cells pre-cultured with HS-5 ACSS2-WT. The gene discussed is RUNX2; the disease is leukemia.