The most valuable target genes were AKT1, MAPK3, IL6, TP53, VEGFA, TNF, SRC, MAPK1, STAT3, EGFR, CXCL8, JUN, CASP3, and MAPK8, suggesting that these 14 targets may be the key of AD with BSYJF treatment. Here, EGFR is linked to Alzheimer disease.