It further phosphorylates SHP-1, downregulating expression and phosphorylation of TRPV1.266,267 The attenuation of sodium channels and potentiation of potassium channels mediated by SHP-1 are observed, inhibiting the excitability of sensory neurons267,268 However, this mechanism can also be exploited by melanoma cells secreting PD-L1, leading to pain relief in the early stages of cancer development.267 The inconspicuous symptoms may contribute to delayed treatment and poor prognosis in cancer patients. This evidence concerns the gene KCNA3 and cancer.