For instance, HDAC2 promotes deacetylation of histone H4, decreasing miR-183 expression and antagonizing its inhibitory effects on TXNIP.321 TET2 upregulates TXNIP expression at the transcriptional level and facilitates progression of diabetic neuropathic pain.322 Activation of TRP family members, TRPV1, TRPA1 and TRPV4, enhances NLRP3 inflammasome activity.47,323,324 Moreover, pathological events, like organelle damage and exposure to crystal, also promote NLRP3 inflammasome activity. The gene discussed is NLRP3; the disease is diabetes mellitus.