CD274 and cancer: It further phosphorylates SHP-1, downregulating expression and phosphorylation of TRPV1.266,267 The attenuation of sodium channels and potentiation of potassium channels mediated by SHP-1 are observed, inhibiting the excitability of sensory neurons267,268 However, this mechanism can also be exploited by melanoma cells secreting PD-L1, leading to pain relief in the early stages of cancer development.267 The inconspicuous symptoms may contribute to delayed treatment and poor prognosis in cancer patients.