Thus atlastin-1-HSP joins the group of HSPs in which neuronal lysosomal dysfunction has been identified, and more broadly joins the group of neurodegenerative conditions, including Alzheimer's disease and Parkinson's disease, in which lysosomal dysfunction likely plays a pathological role (Roney et al., 2022). The gene discussed is HSP90B2P; the disease is early-onset autosomal dominant Alzheimer disease.