Mutations in atlastin-1 cause a predominantly childhood onset HSP that may be pure but which is often accompanied by peripheral neuropathy - in some families the neuropathy is the most troublesome feature and then the condition is termed autosomal dominant hereditary sensory neuropathy type 1D (Guelly et al., 2011; Zhao et al., 2001). Here, ATL1 is linked to hereditary spastic paraplegia.