TP53 and adenocarcinoma: Because GAED and gastric HAC (GHAC) often coexist or overlap, and share similar clinicopathological and genetic features, such as aggressive clinical course, frequent lymphovascular invasion, lymph node and liver metastases, admixture with conventional adenocarcinoma components, and TP53 mutation and ERBB2 amplification [[1], [2], [3]].