Many of the genes in these 5TRa-enriched motif groups are associated with neurodevelopmental and psychiatric disorders (10 out of 182 genes; 3.4-fold enrichment; X2 [1, N = 19,654] = 15.9, p = 7 × 10−5; Table S4), including ASD2: RFX3 (HTH/RFX), TCF4 (bHLH), and NCOA1 (bHLH); neurodevelopmental delay26: CTCF (CTCF/BORIS), YY1 (YY1), ERF (ETS), KLF7 (KLF/SP), TFE3 (bHLH), and MYCN (bHLH); and schizophrenia27: SP4 (KLF/SP). The gene discussed is SP4; the disease is psychiatric disorder.