SPRY4 and neoplasm: In one study, NSCLC tissues were shown to have substantially lower levels of SPRY4-IT1 expression, which were significantly linked to pathological lymph node metastasis (pN) (P = 0.003), pathological stage (P < 0.001), and tumor size (P = 0.001); Hence, SPRY4-IT1 was shown to independently function as a robust risk predictor of NSCLC prognosis in the study [12].