ELOVL4 and spinocerebellar ataxia type 34: To better understand the role of ELOVL4 and its VLC-FA products in the brain, we generated a knock-in rat model of SCA34 (SCA34-KI rat) with insertion of the c.736T > G (p. W246G) ELOVL4 mutation that causes SCA34 using CRISPR-Cas9 gene editing [12, 37].