Secondary linear regression analyses between the GCS and several obesity-related inflammatory markers showed that the GCS was inversely correlated with C-reactive protein (a trend) (beta = -0.004 ng/mL; P = 0.058), while no significant associations were detected with the other inflammatory markers tested [immunoglobulin A, interleukin (IL)-8, IL-1b, tumor necrosis factor-alpha and monocyte chemotactic protein 1; P > 0.1]. The gene discussed is TNF; the disease is obesity due to melanocortin 4 receptor deficiency.