More tumor-infiltrating CD8 + T cells in the low T-C score group would be expected to have a marked influence on immunotherapy, as the classical mechanism behind the anti-PD-1/PD-L1 treatment is that the mutual suppression effect conducted by tumor cells and tumor-infiltrating CD8 + cytotoxic T cells (CTLs) could be abolished by ICBs. Here, CD8A is linked to neoplasm.