In multivariate analysis, low Ki67 expression of primary tumor (OR 3.15[1.67–5.90], p < 0.001) and the application of SLNB (OR 2.40[1.11–5.01], p = 0.022), remained independent factors that were predictive of the alteration in Ki67 expression. The gene discussed is MKI67; the disease is neoplasm.