CD274 and colorectal carcinoma: Another research showed that nifedipine (NIFE), acalcium channel blocker, inhibits calcium influx to impair nuclear factor of activated T cell 2 (NFAT2) dephosphorylation, activation, and nuclear translocation, thus decreasing the expression of PD-L1 on CRC cells and reactivates tumor immune monitoring, which may stimulate or enhance PD-1-based antitumor immunotherapy [28].