HP and anemia (phenotype): 1 < 4000/mm3 or diagnosis based on medical history; 2 < 1500/mm3 or diagnosis based on medical history; 3 ≤ 12 g/dL in women, ≤ 13.5 g/dL in men, or diagnosis based on medical history; 4 anemia with a positive direct Coombs test or anemia with a decreased level of haptoglobin or diagnosis based on medical history; 5 <100,000/mm3 or diagnosis based on medical history