HVCN1 and breast carcinoma: Inhibition of HV1 has been shown to reduce tumor cellproliferation, migration, along with cytokine and matrix metalloproteinaseproduction.23 In breast cancer, xenotransplantationof HV1 knockout breast cancer cells into NOD/SCID-gamma(NSG) mice resulted in tumors with reduced sizes compared to tumorsfrom mice transplanted with wild-type tumor cells.26