KDM6A and esophageal squamous cell carcinoma: In line with recent discovery indicating a significant upregulation of H3K27me3 expression in ESCC tissues is significantly upregulated (45,46), we found an obviously upregulation of KDM6A expression in Kyse150, TE1 and TE10 ESCC cells while it is downregulated in Eca9706 cells compared to HEEC (Figure 8E).