The release of these proteins from fork upon replication restart, and the colocalization of KDM6A/SND1 with RPA1 or EdU in ESCC cells, implying that KDM6A and SND1 are required for ESCC cell survival under the stress caused by genotoxin (Figure 9D, E). The gene discussed is KDM6A; the disease is esophageal squamous cell carcinoma.