Correlation analysis showed a positive correlation between the mutational frequency of genomic stability-related genes including TP53, CDKN2A/2B, PCDHGA4, CFAP206 and EEF1B2 was positively correlated with KDM6A mutation, further supporting that KDM6A dysfunction is closely related to genomic instability in tumor (Figure 8D). The gene discussed is CDKN2A; the disease is neoplasm.