VEGFA and macular degeneration: The top matched analyses were all related to ophthalmic disease models and included mild ocular hypertension versus control (GSE122205, z-score 80.18), diabetic retinopathy induced by streptozotocin versus control (GSE87433, z-score 70.71), macular degeneration anti-ANGPT-TIE2-activating antibody versus mouse IgG antibody (GSE88730, z-score 59.76), diabetic retinopathy induced by strep-tozotocin with subsequent islet transplantation versus control (GSE87433, z-score 59.76) and macular degeneration VEGF-Trap versus mouse IgG antibody (GSE8873, z-score 59.76) (Figure 1F).