We have previously demonstrated that fasting levels of the peptide hormone pancreatic polypeptide (PP) correlate with VAT volume and IHCLC.10 Copy number variation in the NPY Y4R gene, which encodes the cognate PP receptor, has been linked to variation in body mass index and waist circumference.11,12 Fasting PP increases with age and is also elevated in people with type 2 diabetes.13,14 Fasting PP is therefore of interest as a potential common marker linking several conditions associated with increased vascular disease risk. Here, PPY is linked to type 2 diabetes mellitus.