In terms of predictive ability, IL-6 (AUC 0.993, 95% CI 0.985 ~ 1) demonstrated a higher predictive accuracy compared to qSOFA (AUC 0.952, 95% CI 0.928 ~ 0.977), NEWS (AUC 0.824, 95% CI 0.720 ~ 0.929) and SIRS (AUC 0.928, 95% CI 0.888 ~ 0.969).<h4>Conclusions</h4>IL-6 has higher accuracy in predicting septic shock after PCNL compared to qSOFA, SIRS, and NEWS. This evidence concerns the gene IL6 and systemic inflammatory response syndrome.