However, because inhibition of FADD/caspase-8 signaling in keratinocytes triggers TNFR1- and ZBP1-mediated necroptosis and skin inflammation (Figs. 1 and 2), it is not possible to use conditional ablation of FADD or caspase-8 alone to assess the role of FADD/Caspase-8-induced signaling in ZBP1caE-het mice. This evidence concerns the gene CASP8 and dermatitis.