ZBP1 and dermatitis: Importantly, mutation of the ZBP1 Zα domains prevented skin inflammation in RIPK1E-KO mice and perinatal lethality in Ripk1mR/mR mice, as well as intestinal inflammation in FADDE-KO mice [12, 13], arguing that ZBP1 is activated by sensing endogenous Z-nucleic acids via its Zα domains and induces necroptosis and inflammation.