RIPK1 and dermatitis: Our previous studies identified ZBP1 as a potent driver of keratinocyte necroptosis and skin inflammation in mice lacking RIPK1 in keratinocytes or expressing RIPK1 with mutated RHIM [6, 13], suggesting that ZBP1 could be implicated in inducing keratinocyte necroptosis in FADDE-KO mice.