ZBP1 and viral infectious disease: In addition, these studies suggested that the C-terminal part of ZBP1 containing the second and third RHIMs inhibits ZBP1-induced cell death, consistent with previous studies showing that ZBP1-deficient cells reconstituted with constructs expressing ZBP1 with mutated RHIM2 or truncation of the C-terminal part of the protein containing RHIM3 underwent increased death in response to viral infection [33].