However, our previous work in mice lacking FADD in intestinal epithelial cells (IECs) showed that TNFR1 cooperates with ZBP1 to induce necroptosis-mediated gut inflammation, revealing an intricate interplay between TNFR1 and ZBP1 in causing IEC necroptosis [11]. The gene discussed is TNFRSF1A; the disease is inflammation.