Here we show that combined ablation of TNFR1 and ZBP1 fully prevented skin inflammation in FADDE-KO mice, demonstrating that ZBP1-mediated necroptosis drives TNFR1-independent skin inflammation upon keratinocyte-specific inhibition of FADD/caspase-8 signaling. Here, TNFRSF1A is linked to dermatitis.