We showed previously that mice lacking FADD specifically in epidermal keratinocytes (Faddfl/flK14-Cre, hereafter referred to as FADDE-KO mice) developed severe inflammatory skin lesions that were prevented by RIPK3 deficiency, suggesting that necroptosis of FADD-deficient keratinocytes drives skin inflammation [21]. Here, FADD is linked to dermatitis.