TNF and dermatitis: However, ZBP1caE-hetRipk3mR/mR mice showed moderately elevated expression of Cxcl9, Ifi44 and Ifit1 and a trend toward increased expression of Tnf in their skin compared to K14-Cre negative control mice, further supporting that blocking RHIM-dependent RIPK3 signaling did not fully prevent skin inflammation.