Mutation of the RIPK3 RHIM or the RIPK3 phosphorylation sites in MLKL strongly suppressed but could not fully prevent skin lesion development in ZBP1caE-het mice, showing that ZBP1ca induces skin inflammation primarily by triggering RIPK3-MLKL-mediated keratinocyte necroptosis and, to a lesser extent, by necroptosis-independent mechanisms. The gene discussed is RIPK3; the disease is dermatitis.