RRAGC and neoplasm: When all sacrificed mice with tumors identified post hoc were removed from the Kaplan–Meier survival curves, tumor-free RragcS74N/+ and RragcS74C/+ mice still showed a shortened lifespan compared to tumor-free Rragc+/+ mice (Extended Data Fig. 1l, m), indicating that the premature death of Rragcmut/+ mice is not related to differences in spontaneous tumorigenesis.