ISLR and colorectal carcinoma: Meflin, α-SMA (Acta2), and interleukin-6 (IL-6) were expressed in different CAF subsets, consistent with the findings of previous studies suggesting that Meflin+ CAFs are distinct from myCAFs or inflammatory CAFs (iCAFs) in PDAC, CRC, and NSCLC [12, 17, 25, 28, 31].