Importantly, multi-ethnic GWAS (e.g., in cohorts of Asian, Hispanic/Latino and African-American ancestries) have allowed for improved discovery and fine-mapping of genetic loci [17], such as the discovery of the obesity-promoting missense variant in the CREB3 regulatory factor gene (CREBRF) specifically in Samoans [18]. The gene discussed is CREBRF; the disease is obesity due to melanocortin 4 receptor deficiency.