Second, as demonstrated by PROGENy analysis34, the MDA-MB-231 and HCC1937 cell lines are characterized by strong upregulation of the JAK/STAT pathway compared to that in the MCF7 cell line (z scores of -1.732, 1.536, and 2.637 for the MCF7, MDA-MB-231 and HCC1937 cell lines, respectively; data retrieved from https://www.proteinatlas.org/humanproteome/cell+line/Breast+cancer). This evidence concerns the gene SOAT1 and cancer.