AFP and neoplasm: Age (continuous), MELD score (continuous), number of tumour nodules (1 versus 2-3 versus >3), size of the largest nodule (≤3 versus 3-5 versus >5 cm), macrovascular invasion, extrahepatic manifestation, first treatment line (curative versus palliative), AFP (<1000 versus ≥1000) and CRP (<1 versus ≥1) were significantly associated with OS in multivariable analysis as well (Table 4).