Furthermore, circUBE2D2 knockout reduced tumor growth.<h4>Conclusion</h4>CircUBE2D2 regulates the expression of HMGB1 by acting as a sponge of ceRNA as miR-885-5p, thereby promoting the control of OC cell proliferation and migration and inhibiting cell apoptosis. The gene discussed is HMGB1; the disease is neoplasm.