We analyzed the genomes, using shallow whole-genome sequencing (sWGS) and whole-exome sequencing (WES), from 16 cancers of 9 individuals homozygous for the most common loss-of-function (LoF) gPV in CHEK2 (NM_007194.4; c.1100del) (12). The gene discussed is CHEK2; the disease is cancer.