The results showed that the OR value of the IL-8-rs4073 polymorphism merged in the recessive gene model was statistically significant (P = 0.003), indicating a significant reduction in the risk of sepsis in newborns with the TT genotype (OR = 0.467, 95% CI: 0.280–0.777). The gene discussed is CXCL8; the disease is Sepsis.