Under the recessive gene model of TNF-α-308G/A (rs1800629) study, the P-values for Asian, European and global effects were 0.527, 0.474 and 0.408, respectively, which were all greater than 0.05, indicating that there was no correlation between TNF-α-308G/A (rs1800629) gene polymorphism and neonatal sepsis under the recessive gene model. The gene discussed is TNF; the disease is Neonatal sepsis.