In the allele model of IL-8-rs4073 study, the P-values for Asian, European and the global effects were 0.497, 0.094 and 0.087, respectively, which were all greater than 0.05, indicating that there was no correlation between IL-8-rs4073 gene polymorphism and neonatal sepsis under the allele model. The gene discussed is CXCL8; the disease is Neonatal sepsis.