Therefore, this study summarized and analyzed the literature on the correlation between the IL-6 174G polymorphism and neonatal sepsis [34, 36–43], and finally found that the OR value of the IL-6-174G/C polymorphism merged in the recessive gene model was statistically significant (P = 0.005), indicating a significant increase in the risk of neonatal sepsis with the CC genotype (OR = 1.591, 95% CI: 1.154–2.194). The gene discussed is IL6; the disease is Neonatal sepsis.