In the heterozygous gene model of TNF-α-308G/A (rs1800629) study, the P-values for Asian, European and global effects were 0.199, 0.776 and 0.695, respectively, which were all greater than 0.05, indicating that there was no correlation between TNF-α-308G/A (rs1800629) gene polymorphism and neonatal sepsis under the heterozygous gene model. This evidence concerns the gene TNF and Neonatal sepsis.