This study summarizes and analyzes the literature on the association between the IL-8rs4073 polymorphism and neonatal sepsis [36, 44], and found that the OR value of the IL-8-rs4073 polymorphism merged in the recessive gene model was statistically significant(P = 0.003), indicating that the risk of neonatal sepsis was significantly reduced in infants with the TT genotype (OR = 0.467, 95% CI: 0.280–0.777). The gene discussed is CXCL8; the disease is Neonatal sepsis.