In the recessive gene model in TNF-α-308G/A (rs1800629) study, the P-values of the conforming HWE and the overall effects were 0.408 and 0.408, respectively, which were greater than 0.05, indicating that there was no correlation between TNF-α-308G/A (rs1800629) gene polymorphism and neonatal sepsis under the recessive gene model. The gene discussed is TNF; the disease is Neonatal sepsis.