In the homozygous gene model of TNF-α-308G/A (rs1800629) study, the P-values of conforming HWE and the overall effects were 0.171 and 0.171, respectively, which were greater than 0.05, indicating that there was no correlation between TNF-α-308G/A (rs1800629) gene polymorphism and neonatal sepsis under the homozygous gene model. This evidence concerns the gene TNF and Neonatal sepsis.