SHBG and male infertility: The IVW analysis indicated no causal relationship between SHBG and male infertility(OR = 0.954, 95% CI = 0.788–1.155, P = 0.627) Similar results were obtained in the MR-Egger (OR = 0.936, 95% CI = 0.667–1.314, P = 0.703) and weighted median (OR = 1.03, 95% CI = 0.775–1.369, P = 0.841) analyses, as well as the weighted mode method (OR = 0.912, 95% CI = 0.669–1.243, P = 0.56), and they were not significant (Table 2).