ERBB2 and breast carcinoma: The authors compared the ACE genotypes of AC patients with a group of alcohol abusers without signs of cardiomyopathy and found a polymorphism in 57% of AC subjects vs. 7% in the non-AC group.55 Later, Lemieux et al. 56 described a cohort of 237 HER2-positive breast cancer patients treated with trastuzumab, in which the HER2 Ile/Val polymorphism and alcohol intake (<10 drinks/80 g/week) were risk factors for cardiotoxicity.