The variant in CAPN1 and 3 other missense variants, c.3848G>A/p.Gly1283Asp (TNS2), c.419G>A/p.Cys140Tyr (TGM6), c.230C>A/p.Ala77Asp (CCL22) and c.2143C>T/p.Arg715Trp (UNC45B), were associated with heart failure. The gene discussed is CAPN1; the disease is heart failure.