The patient then had endoscopic care.<h4>Diagnoses</h4>Only 1 polypoid lesion on white-light endoscopy in the sigmoid colon was pathologically diagnosed as intestinal T-cell lymphomas, not otherwise specified (ITCL-NOS).<h4>Interventions</h4>The patient underwent intensity-reduced CHOP therapy.<h4>Outcomes</h4>The patient is still with controlled disease but developed chemotherapy-related side effects.<h4>Lessons</h4>In the individual with unexplained anemia and waste, endoscopy should not be delayed. The gene discussed is DDIT3; the disease is anemia (phenotype).