For BC patients, age ≥ 50 years, Ki67 ≥ 0.3, HER2 positive or triple-negative breast cancer subtype, advanced N stage, and no mastectomy were correlated with shorter TPDBM.<h4>Conclusions</h4>This single-institutional study helps identify patients who have a high risk of developing BM early. Here, MKI67 is linked to breast cancer.