C3 and Schnyder corneal dystrophy: In children, the diagnostic 7-biomarker proteomics panel consisting of ALDOA, C3, LPA, PFN1, PYGB, TLN1, and THBS1 can identify HCM from controls with high sensitivity and specificity, while the 4-biomarker prognostic panel consisting of APOL1, C5b, IGHE, and SAA4 identifies children at high risk of SCD, predicting mortality and adverse arrhythmic outcomes.