Platelets have been reported to influence cancer progression, metastasis, and angiogenesis in multiple ways, such as protecting tumor cells from high shear forces in the blood circulation and leukocyte attack and binding to C-type lectin-like receptor 2 (CLEC-2) to facilitate hematogenous cancer metastasis and cancer-associated thrombosis (12, 51). Here, CLEC1B is linked to cancer.