Previous studies have also demonstrated the importance of MIF in kidney-related conditions like acute kidney injury (AKI), chronic kidney disease (CKD), diabetic nephropathy, autosomal dominant polycystic kidney disease (ADPKD), and vasculitides (27–35).In glomerulonephritis, inhibition of MIF by neutralizing antibodies has shown renal protective in IgA nephritis and in rats with crescentic GN (36–38). This evidence concerns the gene MIF and chronic kidney disease.