CXCL16 and Hepatic fibrosis: On the other hand, liver NKT cells accumulate in a CXCR6-dependent manner early after injury, exacerbating the inflammatory response and promoting the progression of liver fibrosis, suggesting that the CXCR6/CXCL16 pathway may be an effective target for the treatment of liver fibrosis (Wehr et al., 2013).